We have started the year with two papers in the area of global health drug discovery. Firstly, a paper from Dennis with collaborators from UC Merced and Ohio State University on amino acyl t-RNA sythetase inhibitors in Leishmania. Secondly, a mode of action story featuring salinipostin A, a compounds for our lab from 2015. This was led by Euna Yoo and the Bogyo lab, and features former student Chris Schulze, and postdoc Kenji Kurita. Congratulations to all. DOI: 10.1371/journal.pntd.0007983